Enjoying victimhood, Lev?
Lev just called you a sadomasochist … a psychosadomasochist. But who enjoys depression?
PS: Talking about long words beginning with “psycho”, there’s one I hate: psychopharmocology. Pseudo-scientific bunkum disguised in white collar criminality.
I’ll take the liberty of sharing with you an email I received. I can’t help this guy… is there anyone out here who can?
Here it is:
#1:
[i]you may help me solve one problem to which I got due to a mistake made by a doctor. I was misdiagnozed with schizophernia and treated with atypical antipsychotics for roughly two months. I’d say it was a heavy treatment.
I did some research about issues associated with antipsychotics mode of action, and I have a suspicion that my dopamine receptors (particularly D2 and D3) stayed upregulated to a certain extent above normal. I wonder if you can assess or estimate the extent of DA receptor upregulation based on a dosing regimen and a time that passed since the last dose. I would send you the dosing regimen.
This information would greatly help me because I could work with it further.[/i]
#2:
Nice to get to know you too!
<<But I’m afraid that I’m no expert in this very specific area of biochemistry.>… he’s quoting me…>
[i] And do you know someone who is?
I’m sending it in an attachment.
I’m actually applying the method for downregulation of DA receptors by levodopa use (studies confirmed this). I feel a lot better, but in fact, I’m not really sure whether there is still an upregulation. Neither I’m not sure how much levodopa daily is needed for downregulation and for how long.
Is there any need for cannabis, then?[/i]
<<You know… as always, I’d advised him to explore cannabis>>
Attachment:
[i]Treatment lasted about 2 months.
First 48 days (daily, taken together):
- Sulpiride 3 x 50 mg
- Olanzapine 3 x 5 mg
- Clonazepam 2 mg
Note: In first 2-4 weeks (don’t know the duration), the Sulpiride and Olanzapine were replaced by these:
- Risperidone 1 mg (max 3x daily)
- Amisulpride 50 mg (max 3x daily)
Next 21 days (daily, taken together):
- Sulpiride 3 x 50 mg
- Olanzapine 2 x 10 mg
- Clonazepam 2 x 0.5 mg
I titrated off the medication in about a week, in January 2016.
Then, from June to September (4 months) I took Cabergoline 0.5 mg twice a week to lower prolactin.
I know that it’s relatively long time since last dose, but from my observation and from experiences of other people, I believe that my DA receptors must still be upregulated to a certain extent (+ lowered DA levels and neurotransmission), because it is said that upregulation (caused by medication or not) itself decreases neurotransmitter levels, and for downregulation, you need to “flood” receptors with it’s ligands, and since there is lowered DA activity, I assume that it would take some time to down-regulate receptors to optimal density and at the same time balance DA levels and neurotransmission to optimal state, in my opinion.[/i]