Crispr whisperer

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Crispr whisperer

Postby Persefonie » Mon Nov 18, 2019 12:47 am

Shalom and Greetings

Newb here so please be gentle, I know a few of you are prone to guns and knives so...

The dawn of a new era surrounding our very own genetic code is imminent, already many malignancies are being edited out of our genome. Sure thing there might be a few issues we are still dealing with, but the field is expanding at an explosive rate, and truly the only factor stopping us is money. What I mean to say is that it took trillions to create the global health system you see now, replacing outdated archaic methods costs money, and by the time we have everything in place it too will be outdate.

Humanity is on the brink of an evolutionary leap, one which most of us on this forum will not see with their current eyes, but do not despair, your offspring will be more fortunate.

The Stars are beckoning, more and more science is resembling magic, myth and fact are coming to a point that they will be indistinguishable and all that is lagging is man's propensity for individualism, based on a foundation of lies. Driven by hedonism and the need to be unique we are being led to a stale mate as we keep pushing that dopamine button in hope of another treat; who the freak put us in this shit maze anyway?

Don't answer that. And please indulge my ranting.

Where was eye? Oh yes Crispr.

So get this: No Death, No DAATH, no Otherside, no getting old and cold, nothing but the endless void of our own heads. That would be good and well if it was any other Void, but no, we get to roam the cosmos like the undying lizards we will become, with Arch-Lizards dictating our every move. Forever.

Feckin splendid.

Is it me or does there seem to be a 'Self destruct' mechanism embedded into our very being in order for this specific thing not to occur? Is this what the Elohim meant when they said ' ...lest they eat from the Tree of Life and Live forever/become like Us' Gen 3:22? Or was this just a metaphorical reference to a-priori knowledge concerning the Fruit of the metaphorical Quabbalistic Tree?

Finally I might post this topic twice as I am prone to pressing buttons.

Pax
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Re: Crispr whisperer

Postby Persefonie » Mon Nov 18, 2019 9:53 pm

Shalom and Welcome

So...as if right on cue American Scientists have stepped up and announced their first treatments using crispr/cas9 technology.
Doctors at the University of Pennsylvania Abramson Cancer Centre used the technology on patients in their 60s whose cancer had progressed despite undergoing regular treatments.

A DNA editing tool used to snip defective genes in unborn children is being tested in the United States to fight cancer, New York Times reported.
For the first time outside of China, tests on three patients with advanced cancer were conducted to see how effective the DNA-snipping tool CRISPR-Cas9 (CRISPR) is. Until recently Crispr technology had been used exclusively on embryos, now we branch on to fully developed humans.

“It’s the most complicated genetic, cellular engineering that’s been attempted so far,” the centre’s Section Chief of Hematologic Malignancies Dr Edward Stadtmauer told the NY Times.


Watch this space

Pax et Lux
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Re: Crispr whisperer

Postby Dan~ » Mon Nov 18, 2019 10:04 pm

Things always start off in a primative state,
then they become technologies over time.
Even one step is important.
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Early response is positive

Postby Persefonie » Wed Nov 20, 2019 5:03 pm

Shalom and welcome....

The first patients in each of two early-stage clinical trials testing CRISPR-based treatments for inherited blood disorders have been symptom free for several months with normalized hemoglobin levels, the companies developing the therapies announced today. Both participants experienced only treatable, temporary side effects, according to the data.

Last fall, Switzerland-headquartered CRISPR Therapeutics and Vertex Pharmaceuticals in Boston teamed up to launch a trial in Germany testing a CRISPR-based approach to treating β-thalassemia. The therapy, known as CTX001, is applied to blood stem cells removed from the patient to cleave the BCL11A gene that represses the production of fetal hemoglobin. These cells are then reinfused to provide a healthy supply this protein, normally only produced in infancy, to overcome problems associated with mutations in the gene encoding the adult version. A few months later, the two companies launched a parallel trial in Nashville, Tennessee, to test CTX001 in sickle cell patients, who also suffer from mutations in the gene for adult hemoglobin.

The data released this week pertains to the first patients treated, one in each of these trials. In both participants, the CRISPRed cells successfully homed to the bone marrow. In the nine months since she received the treatment, the β-thalassemia patient has required no blood transfusions, which she had needed regularly for 16 years, and her total hemoglobin levels are near-normal, STAT reports. Meanwhile, the sickle-cell patient has not suffered any of the painful and organ-damaging events known as vaso-occlusive crises, where the misshapen blood cells characteristic of the disease stick to and clog small blood vessels, since she received her treatment in July, and her total hemoglobin levels have also normalized, according to STAT.

“We are very, very excited,” Haydar Frangoul, the treating physician at the Sarah Cannon Research Institute in Nashville, tells NPR. “This preliminary data shows for the first time that gene editing has actually helped a patient with sickle cell disease. This is definitely a huge deal.”

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Re: Crispr whisperer

Postby MagsJ » Wed Nov 20, 2019 10:19 pm

Its all well and good curing people of their ills, but will these ills still be inheritable/transferable to their offspring?
The possibility of anything we can imagine existing is endless and infinite

I haven't got the time to spend the time reading something that is telling me nothing, as I will never be able to get that time back, and I may need it for something at some point in time. Wait! What?

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Re: Crispr whisperer

Postby Aware-ness » Wed Nov 20, 2019 11:44 pm

Persefonie wrote:Is it me or does there seem to be a 'Self destruct' mechanism embedded into our very being

Fret not. We'll just edit that out of our genome.
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Re: Crispr whisperer

Postby Aegean » Sun Dec 08, 2019 12:29 am

Allahu Akbar, may the true lord shine upon you.

There's a temple outside Sparta, dedicated to which Deity?
What have they built upon it?

Listened to a concert, under the stars, once under its tree.

Stood on the walls, giving a speech, like Lycurgus.
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